Paradoxical reactions and immune reconstitution inflammatory syndrome in tuberculosis

Highlights • Case definitions for paradoxical reactions and immune reconstitution inflammatory syndrome (IRIS) in tuberculosis (TB) are reviewed. • The risk factors and immunopathogenesis of these conditions are explored. • Pathogenesis is discussed in the context of recent advances in TB research....

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Veröffentlicht in:International journal of infectious diseases 2015-03, Vol.32 (C), p.39-45
Hauptverfasser: Bell, Lucy C.K, Breen, Ronan, Miller, Robert F, Noursadeghi, Mahdad, Lipman, Marc
Format: Artikel
Sprache:eng
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Zusammenfassung:Highlights • Case definitions for paradoxical reactions and immune reconstitution inflammatory syndrome (IRIS) in tuberculosis (TB) are reviewed. • The risk factors and immunopathogenesis of these conditions are explored. • Pathogenesis is discussed in the context of recent advances in TB research. • A hypothesis is proposed for their core underlying pathogenesis.
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2014.12.030