Virological Traits of the SARS-CoV-2 BA.2.87.1 Lineage

Transmissibility and immune evasion of the recently emerged, highly mutated SARS-CoV-2 BA.2.87.1 are unknown. Here, we report that BA.2.87.1 efficiently enters human cells but is more sensitive to antibody-mediated neutralization than the currently dominating JN.1 variant. Acquisition of adaptive mu...

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Veröffentlicht in:	Vaccines (Basel) 2024-05, Vol.12 (5), p.487
Hauptverfasser:	Zhang, Lu, Dopfer-Jablonka, Alexandra, Nehlmeier, Inga, Kempf, Amy, Graichen, Luise, Calderón Hampel, Noemí, Cossmann, Anne, Stankov, Metodi V, Morillas Ramos, Gema, Schulz, Sebastian R, Jäck, Hans-Martin, Behrens, Georg M N, Pöhlmann, Stefan, Hoffmann, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 binding Amino acids Antibodies antibody evasion BA.2.87.1 Cells COVID-19 vaccines Ethylenediaminetetraacetic acid Experiments Health aspects host cell entry Kinases Mutation Neutralization Pandemics Plasmids Proteins Resveratrol RNA SARS-CoV-2 Scientific equipment and supplies industry Severe acute respiratory syndrome coronavirus 2 spike protein Sucrose Vaccines Viral antibodies
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Beschreibung
Zusammenfassung:	Transmissibility and immune evasion of the recently emerged, highly mutated SARS-CoV-2 BA.2.87.1 are unknown. Here, we report that BA.2.87.1 efficiently enters human cells but is more sensitive to antibody-mediated neutralization than the currently dominating JN.1 variant. Acquisition of adaptive mutations might thus be needed for efficient spread in the population.
ISSN:	2076-393X 2076-393X
DOI:	10.3390/vaccines12050487