Bis(2,2,2 trifluoroethyl) Phosphonate as a Convenient Precursor for the Synthesis of H-Phosphonates

Bis(2,2,2 trifluoroethyl) Phosphonate as a Convenient Precursor for the Synthesis of H-Phosphonates

A microwave-assisted synthesis of dialkyl and cyclic H-phosphonates via bis(2,2,2 trifluoroethyl) phosphonate (BTFEP) is described. This method enables the synthesis of various cyclic H-phosphonates and hetero-substituted dialkyl H-phosphonates by simple alcoholysis under non-inert and additive-free...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2024-05, Vol.29 (11), p.2432
Hauptverfasser: Pohl, Jean-Marie, Stöhr, Fabian, Kramer, Tim, Becker, Jonathan, Göttlich, Richard
Format: Artikel
Sprache:eng
Schlagworte:
Alcohol
Chemical properties
Decomposition
dialkyl phosphite
dioxaphospholane
Equilibrium
H-phosphonate
Investigations
microwave
Molecular weight
Phosphates
Phosphonates
Polymerization
Reproducibility
Temperature
transesterification
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Zusammenfassung:A microwave-assisted synthesis of dialkyl and cyclic H-phosphonates via bis(2,2,2 trifluoroethyl) phosphonate (BTFEP) is described. This method enables the synthesis of various cyclic H-phosphonates and hetero-substituted dialkyl H-phosphonates by simple alcoholysis under non-inert and additive-free conditions. Short reaction times and the requirement for only stoichiometric amounts of alcohol render this method attractive for synthetic applications.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29112432