FIXED ETIOPATHOGENETIC COMBINATION OF DRUGS TO TREAT ARTERIAL HYPERTENSION

Fixed combinations of antihypertensive drugs are more actively used in practice for therapy of arterial hypertension and on the whole are positively assessed by doctors and by patients. The accumulated experience of separate application of drugs allowed defining variants of their rational combination and to formulate the following major criteria of joint application: presence of different and mutually reinforcing mechanisms of actions; validity of the greater effectiveness of combination with proof of good tolerability and presence of the fewer side effects. Currently the process of development of new fixed combinations of antihypertensive drugs is going on and the strategy of their application is made more precise taking into account the degree of the disease severity and the cardiovascular risk.