The Efficacy of Aprotinin Combinations with Selected Antiviral Drugs in Mouse Models of Influenza Pneumonia and Coronavirus Infection Caused by SARS-CoV-2

The efficacy of aprotinin combinations with selected antiviral-drugs treatment of influenza virus and coronavirus (SARS-CoV-2) infection was studied in mice models of influenza pneumonia and COVID-19. The high efficacy of the combinations in reducing virus titer in lungs and body weight loss and in...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2022-08, Vol.27 (15), p.4975
Hauptverfasser:	Ivashchenko, Andrey A, Zagribelnyy, Bogdan A, Ivanenkov, Yan A, Ivashchenko, Ilya A, Karapetian, Ruben N, Kravchenko, Dmitry V, Savchuk, Nikolay P, Yakubova, Elena V, Ivachtchenko, Alexandre V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Antiviral agents Antiviral drugs Aprotinin Bacterial pneumonia Body weight Body weight loss Coronaviruses COVID-19 Dosage and administration Drug therapy Drug therapy, Combination Drugs Infections Influenza Mortality Pneumonia SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Survival Testing Viruses Weight loss
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Beschreibung
Zusammenfassung:	The efficacy of aprotinin combinations with selected antiviral-drugs treatment of influenza virus and coronavirus (SARS-CoV-2) infection was studied in mice models of influenza pneumonia and COVID-19. The high efficacy of the combinations in reducing virus titer in lungs and body weight loss and in increasing the survival rate were demonstrated. This preclinical study can be considered a confirmatory step before introducing the combinations into clinical assessment.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules27154975