Spread of multidrug resistance in non-PCV13/PCV20 serotypes of Streptococcus pneumoniae: A cross-sectional study ten years after the introduction of pneumococcal conjugate vaccine in Japan

Ten years after the introduction of the pneumococcal conjugate vaccine (PCV) in Japan, the prevalence rates of non-PCV13 and non-PCV20 serotypes among pediatric pneumococcal isolates were 94.0% and 73.7%, respectively. The predominant non-PCV13/PCV20 serotypes (15A, 35B, and 23A) were mostly multidr...

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Veröffentlicht in:	Journal of microbiology, immunology and infection immunology and infection, 2023-12, Vol.56 (6), p.1288-1292
Hauptverfasser:	Kawaguchiya, Mitsuyo, Urushibara, Noriko, Aung, Meiji Soe, Ohashi, Nobuhide, Takamatsu, Rika, Tsutida, Sho, Ito, Masahiko, Kobayashi, Nobumichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimicrobial susceptibility Child Cross-Sectional Studies Drug Resistance, Multiple Humans Japan Japan - epidemiology Pneumococcal conjugate vaccines (PCVs) Pneumococcal Infections - epidemiology Pneumococcal Infections - prevention & control Pneumococcal Vaccines Serogroup Serotype Serotyping Streptococcus pneumoniae Vaccines, Conjugate
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Zusammenfassung:	Ten years after the introduction of the pneumococcal conjugate vaccine (PCV) in Japan, the prevalence rates of non-PCV13 and non-PCV20 serotypes among pediatric pneumococcal isolates were 94.0% and 73.7%, respectively. The predominant non-PCV13/PCV20 serotypes (15A, 35B, and 23A) were mostly multidrug-resistant (≥80.5%), exhibiting non-susceptibility to penicillin.
ISSN:	1684-1182 1995-9133
DOI:	10.1016/j.jmii.2023.07.004