Antiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruits

This study assessed the activity of compounds from Piper tuberculatum against Plasmodium falciparum and Leishmania guyanensis. The effects of compounds from P. tuberculatum fruits on P. falciparum and L. guyanensis promastigote growth in vitro were determined. Hemolytic action and cytotoxicity in He...

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Veröffentlicht in:	Revista da Sociedade Brasileira de Medicina Tropical 2018-04, Vol.51 (3), p.382-386
Hauptverfasser:	Oliveira, Flávio Augusto de Souza, Passarini, Guilherme Matos, Medeiros, Daniel Sol Sol de, Santos, Ana Paula de Azevedo, Fialho, Saara Neri, Gouveia, Aurileya de Jesus, Latorre, Marcinete, Freitag, Elci Marlei, Medeiros, Patrícia Soares de Maria de, Teles, Carolina Bioni Garcia, Facundo, Valdir Alves
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiprotozoal agents Antiprotozoal Agents - isolation & purification Antiprotozoal Agents - pharmacology Bioactivity Cytotoxicity Erythrocytes Fruit - chemistry Fruits Hep G2 Cells - drug effects Humans Inhibitory Concentration 50 Leishmania guyanensis - drug effects Leishmaniasis Malaria Phanoderma tuberculatum Piper Piper - chemistry Plant Extracts - pharmacology Plasmodium falciparum Plasmodium falciparum - drug effects Toxicity Toxicity Tests TROPICAL MEDICINE
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Zusammenfassung:	This study assessed the activity of compounds from Piper tuberculatum against Plasmodium falciparum and Leishmania guyanensis. The effects of compounds from P. tuberculatum fruits on P. falciparum and L. guyanensis promastigote growth in vitro were determined. Hemolytic action and cytotoxicity in HepG2 and J774 cells were measured. Three compounds showed strong antiplasmodial activity and one compound showed strong antileishmanial activity. Two compounds were non-toxic to HepG2 cells and all were toxic to J774 cells. The compounds showed no hemolytic activity. The tested compounds from P. tuberculatum exhibited antiparasitic and cytotoxic effects.
ISSN:	0037-8682 1678-9849 1678-9849
DOI:	10.1590/0037-8682-0309-2017