Shape of the OGTT glucose response curve: relationship with β-cell function and differences by sex, race, and BMI in adults with early type 2 diabetes treated with metformin

IntroductionThe shape of the glucose curve during an oral glucose tolerance test (OGTT) reflects β-cell function in populations without diabetes but has not been as well studied in those with diabetes. A monophasic shape has been associated with higher risk of diabetes, while a biphasic pattern has...

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Veröffentlicht in:	BMJ open diabetes research & care 2021-09, Vol.9 (1), p.e002264
Hauptverfasser:	Utzschneider, Kristina M, Younes, Naji, Rasouli, Neda, McKee, MD, Rhee, M, Wilson, P, Boers, J, Gullett, C, Mungara, R, Savoye, L, Holloway, L, Roe, E, Chionh, K, Iacoboni, J, Sanders, C, Hausheer, C, Green, JB, Feinglos, MN, Evans Kreider, K, Lteif, A, Mullen, M, Aguillar, D, Hurt, S, Carlson, A, Martin, D, Willis, H, Herson, M, Mularski, K, Ramey, PA, Kauffman, B, Berame, K, Ghioni, D, Gluth, J, Jones, S, Nazarov, S, Puttnam, R, Ojoawo, B, Stokes, K, Curtis, M, Kolli, A, Chambers, B, Dushkin, A, Cayford, M, Chu, K, Thangthaeng, N, Kochis, R, Park, J, Garg, R, Valencia, WM, Riccio Veliz, AK, Gutt, M, Aby-Daniel, D, Joarder, F, Cady, N, Rivera-Eschright, N, Matwichyna, M, Ishii, RR, Greenway, FL, Mudaliar, S, Garcia-Acosta, D, Maggs, S, DeLue, C, Curtis, JM, Joshevama, E, Karshner, T, Pi-Sunyer, FX, Frances, S, Cherian, A, Bergamo, K, Culmer, D, Josey, K, Fuller, G, Cherrington, A, Cohen, RM, Craig, J, Kersey, K, Rasouli, N, Schroeder, E, Sivitz, W, Knosp, L, Tan, MH, Waltje, A, Bule, S, Seaquist, ER, Kumar, A, Lesne, L, Smith, S, Desouza, C, Kuechenmeister, L, Morales, AL, Alfred, A, Eggert, J, Lord, G, Tillson, R, Schade, DS, Duran-Valdez, E, Martinez, J, August, P, Rodriguez, MG, Griffith, O
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antidiabetics Body Mass Index Cross-Sectional Studies Diabetes diabetes mellitus Diabetes Mellitus, Type 2 - drug therapy Female Glucose Glucose Tolerance Test Humans Immunoassay Insulin Laboratories Male Metabolism Metformin - therapeutic use OGTT Peptides type 2
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Zusammenfassung:	IntroductionThe shape of the glucose curve during an oral glucose tolerance test (OGTT) reflects β-cell function in populations without diabetes but has not been as well studied in those with diabetes. A monophasic shape has been associated with higher risk of diabetes, while a biphasic pattern has been associated with lower risk. We sought to determine if phenotypic or metabolic characteristics were associated with glucose response curve shape in adults with type 2 diabetes treated with metformin alone.Research design and methodsThis is a cross-sectional analysis of 3108 metformin-treated adults with type 2 diabetes diagnosed
ISSN:	2052-4897 2052-4897
DOI:	10.1136/bmjdrc-2021-002264