Correlation between N‐terminal pro‐atrial natriuretic peptide, corin, and target organ damage in hypertensive disorders of pregnancy

The objective was to evaluate the correlation between N‐terminal pro‐atrial natriuretic peptide (NT‐proANP), corin and the severity of target organ injury in hypertensive disorders of pregnancy. A total of 78 women with hypertensive disorders of pregnancy and 49 normotensive pregnancies were enrolle...

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Veröffentlicht in:	The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2022-05, Vol.24 (5), p.644-651
Hauptverfasser:	Zhang, Wei, Zhou, Ying, Dong, Yubing, Liu, Wanyu, Li, Haiying, Song, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Atrial Natriuretic Factor - metabolism Biomarkers Biomarkers - metabolism Blood pressure Body mass index Cardiomyopathy Cardiovascular disease Case-Control Studies Cholesterol corin Creatinine Creatinine - metabolism Eclampsia Enzymes Female Gestational age Heart Atria - metabolism Heart failure High density lipoprotein Humans Hypertension Hypertension, Pregnancy-Induced - diagnosis Hypertension, Pregnancy-Induced - metabolism Hypertension, Pregnancy-Induced - pathology hypertensive disorders of pregnancy Kidney diseases Kinases N‐terminal pro‐atrial natriuretic peptide Original Peptides placental growth factor Preeclampsia Pregnancy Protein Precursors - metabolism Proteins Serine Endopeptidases - metabolism soluble FMS‐like tyrosine kinase Urine Uterus Vascular endothelial growth factor Womens health
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Zusammenfassung:	The objective was to evaluate the correlation between N‐terminal pro‐atrial natriuretic peptide (NT‐proANP), corin and the severity of target organ injury in hypertensive disorders of pregnancy. A total of 78 women with hypertensive disorders of pregnancy and 49 normotensive pregnancies were enrolled. The clinical characteristics, laboratory index and echocardiogram results were collected. NT‐proANP, corin, sFlt‐1 and PlGF levels were measured. A receiver's operating characteristics (ROC) curve was performed to evaluate the efficacy of predicting target organ injury in the HDP group. The NT‐proANP, corin, and sFlt‐1/PlGF ratio were increased in the HDP group (p
ISSN:	1524-6175 1751-7176
DOI:	10.1111/jch.14450