Synergistic Effects of Omeprazole and Metformin on Glycemic Control in Type 2 Diabetic Patients. A Randomized Clinical Study

Objective: To evaluate the synergistic effects of omeprazole and metformin on glycemic control among patients with type 2 diabetes. Method: This randomized interventional clinical study was conducted in the Department of Pharmacology and Therapeutics, Basic Medical Sciences Institute, Jinnah post graduate medical Centre Karachi. Total study period was 10 months (august 2014-June2015) with individual study period of 3 months (90 days), Eighty(80) type 2 diabetic patients (40 in each group) of either sex, ages ranged from 30 to 60 years without any known comorbidities were included. Group-A was treated with metformin alone and Group-B was treated with metformin plus omeprazole. Efficacy was evaluated by means of FBG, and HbA1C. Results: Out of 80 patients, 74 had completed the study. Group B showed significant reduction (P=0.001) in terms of FBS and HbA1c level when comparison was done on day 90 with Group A and within group as compared to day 0. Conclusion:-Addition of proton pump inhibitor with metformin was found effective in achieving better glycemic control in type 2 diabetic patients.