Twelve-year Experience for Tenosynovial Giant Cell Tumors of Tendon Sheath: A Review of 95 Cases from A Single Institution

Objective: We aimed to present our 12-year experiences for tenosynovial giant cell tumors (TGCTs) of tendon sheath by summarizing the demographic characteristics and clinicopathological features of 95 cases who underwent excision of localized TGCT in a single institution to investigate the factors associated with gender and tumor location among the patients. Method: The medical records of 95 patients with TGCT were reviewed. Demographic characteristics and clinicopathological findings were collected and compared according to gender and tumor location. Results: Females were predominantly involved (78.95%). The mean age was 41.09±14.26 years. The majority of patients had TGCT in their hands (75.79%) and most predominantly involved tumors in D1 and D2 (n=21 and 25, respectively). The tumor invaded into the bone/joint of 5 patients (5.26%), and 4 recurrences (4.21%) were determined over the mean follow-up period of 84.3 months (range: 14-136). No significant difference was found in demographics and clinicopathological features between two genders (p>0.05). However, there was a significant increase in the median tumor size of male patients compared with that of females (p=0.011). There was also no significant difference in demographics and clinicopathological features among digits of hands (p>0.05). Conclusion: Our study provides a comprehensive analysis of 95 patients who underwent surgical resection for localized TGCTs over 12 years at a single tertiary care hospital. TGCTs pose unique challenges in management because of their diverse clinical presentations and variable recurrence rates. Despite being predominantly benign, TGCTs exhibit recurrence and bone/joint invasion, necessitating meticulous follow-up and evaluation.