Improvement of oral bioavailability of lovastatin by using nanostructured lipid carriers

Nanostructured lipid carriers (NLCs) have been one of the systems of choice for improving the oral bioavailability of drugs with poor water solubility. In the present study, lovastatin (LVT)-loaded NLCs (LVT-NLCs) were successfully prepared by hot high-pressure homogenization method with high entrap...

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Veröffentlicht in:	Drug design, development and therapy development and therapy, 2015-01, Vol.9 (default), p.5269-5275
Hauptverfasser:	Zhou, Jun, Zhou, Daxin
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Analysis Animals Bioavailability Biological Availability Biomarkers - blood Chemistry, Pharmaceutical Cholesterol Cholesterol - blood Cholesterol, HDL - blood Disease Models, Animal Dosage and administration Drug Carriers Drug delivery systems Drug Stability Drugs Entrapment Erosion Hemodialysis Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - chemistry Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics Hyperlipidemias - blood Hyperlipidemias - diagnosis Hyperlipidemias - drug therapy Innovations Lipids Lovastatin Lovastatin - administration & dosage Lovastatin - chemistry Lovastatin - pharmacokinetics Male Medical research Medicine Models, Chemical Morphology Nanoparticles Nanostructure Original Research Particle size Particle size distribution Pharmacodynamics Pharmacology Phase separation Polydispersity Rats, Wistar Size distribution Solubility Stability Surfactants Technology, Pharmaceutical - methods Testing Vehicles
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Zusammenfassung:	Nanostructured lipid carriers (NLCs) have been one of the systems of choice for improving the oral bioavailability of drugs with poor water solubility. In the present study, lovastatin (LVT)-loaded NLCs (LVT-NLCs) were successfully prepared by hot high-pressure homogenization method with high entrapment efficiency, drug loading, and satisfactory particle size distribution. The particles had almost spherical and uniform shapes and were well dispersed with a particle size of
ISSN:	1177-8881 1177-8881
DOI:	10.2147/DDDT.S90016