Survival of Lung Cancer Patients Dependent on the LOH Status for DMP1 , ARF , and p53

Lung cancer is the leading cause of cancer deaths in the world, and accounts for more solid tumor deaths than any other carcinomas. The prognostic values of , , and p53-loss are unknown in lung cancer. We have conducted survival analyses of non-small cell lung cancer (NSCLC) patients from the University of Minnesota VA hospital and those from the Wake Forest University Hospital. Loss of Heterozygosity (LOH) for h was found in 26 of 70 cases (37.1%), that of the locus was found in 33 of 70 (47.1%), and that of the locus in 43 cases (61.4%) in the University of Minnesota samples. LOH for h was associated with favorable prognosis while that of predicted worse prognosis. The survival was much shorter for -loss than -loss, emphasizing the importance of in human NSCLC. The adverse effect of LOH on NSCLC patients' survival was neutralized by simultaneous loss of the h locus in NSCLC and breast cancer, suggesting the possible therapy of epithelial cancers with metastatic ability.