A Analysis of TNF-α, IL6, IL1-α, IL-10 and TGF-β1 Genes Expression in Acute Myeloid Leukemia Patients in Iranian Patients

Acute myeloid leukemia as one of the most common malignant disorders in adults is a heterogeneous clonal disorder of blood producing cells. The aim of this study was to analyze the expression of TNF-α, IL6, IL1-α, IL-10 and TGF-β1 gene in acute myeloid leukemia at diagnosis. The current study was co...

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Veröffentlicht in:Basic and clinical cancer research 2023-02, Vol.14 (1)
Hauptverfasser: Ali Ghorbani Ranjbary, mohammad kajiyazdi
Format: Artikel
Sprache:eng
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Zusammenfassung:Acute myeloid leukemia as one of the most common malignant disorders in adults is a heterogeneous clonal disorder of blood producing cells. The aim of this study was to analyze the expression of TNF-α, IL6, IL1-α, IL-10 and TGF-β1 gene in acute myeloid leukemia at diagnosis. The current study was conducted on 50 patients with acute myeloid leukemia and 50 subjects as control group. Serum levels of TNF-α, IL6, IL1-α, IL-10 and TGF-β1 were measured by ELISA. The RNA was extracted, and the expression of TNF-α, IL6, IL1-α, IL-10 and TGF-β1 gene was evaluated using real-time PCR (ΔΔCT computational) after cDNA synthesis. Statistical analysis was performed using Statistical Package for the Social Sciences 19, and P
ISSN:2228-6527
2228-5466