612 Racial and ethnic disparities in patients with incomplete lupus erythematosus

Patients with incomplete lupus erythematosus (ILE) have features of systemic lupus erythematosus (SLE) but do not satisfy classification criteria for this condition. Some of these ILE patients are at risk for development of SLE. An ongoing multicenter, double-blind, placebo- controlled, NIH-sponsored project, the Study of Anti-Malarials in Incomplete Lupus Erythematosus, the SMILE trial, is investigating whether treatment of ILE patients with hydroxychloroquine slows accumulation of SLE criteria. Although SLE is a condition that disproportionately affects non-White individuals, including Blacks and Hispanics, these groups were under-represented in the SMILE participants. For example, the SMILE site with highest Black enrollment (47%) was Medical University of South Carolina, but this was significantly less than the proportion of Black patients in their SLE cohort (78%; p