Low Susceptibility of Pigs against Experimental Infection with HPAI Virus H5N1 Clade 2.3.4.4b

We found that nasal and alimentary experimental exposure of pigs to highly pathogenic avian influenza virus H5N1 clade 2.3.4.4b was associated with marginal viral replication, without inducing any clinical manifestation or pathological changes. Only 1 of 8 pigs seroconverted, pointing to high resist...

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Veröffentlicht in:	Emerging infectious diseases 2023-07, Vol.29 (7), p.1492-1495
Hauptverfasser:	Graaf, Annika, Piesche, Ronja, Sehl-Ewert, Julia, Grund, Christian, Pohlmann, Anne, Beer, Martin, Harder, Timm
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Avian flu Avian influenza Brain Development and progression Disease susceptibility Disease transmission Diseases Epidemics H5N1 Hogs HPAIV Infections Influenza A virus Influenza A Virus, H5N1 Subtype Influenza in Birds Laboratories mammal Mutation panzootic pigs Research Letter Risk factors Swine Virus Replication Viruses Zoonoses zoonosis
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Zusammenfassung:	We found that nasal and alimentary experimental exposure of pigs to highly pathogenic avian influenza virus H5N1 clade 2.3.4.4b was associated with marginal viral replication, without inducing any clinical manifestation or pathological changes. Only 1 of 8 pigs seroconverted, pointing to high resistance of pigs to clade 2.3.4.4b infection.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2907.230296