Genomic characterization of chronic lymphocytic leukemia (CLL) in radiation-exposed Chornobyl cleanup workers

Chronic lymphocytic leukemia (CLL) was the predominant leukemia in a recent study of Chornobyl cleanup workers from Ukraine exposed to radiation (UR-CLL). Radiation risks of CLL significantly increased with increasing bone marrow radiation doses. Current analysis aimed to clarify whether the increas...

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Veröffentlicht in:	Environmental health 2018-05, Vol.17 (1), p.43-9, Article 43
Hauptverfasser:	Ojha, Juhi, Dyagil, Iryna, Finch, Stuart C, Reiss, Robert F, de Smith, Adam J, Gonseth, Semira, Zhou, Mi, Hansen, Helen M, Sherborne, Amy L, Nakamura, Jean, Bracci, Paige M, Gudzenko, Nataliya, Hatch, Maureen, Babkina, Nataliya, Little, Mark P, Chumak, Vadim V, Walsh, Kyle M, Bazyka, Dimitry, Wiemels, Joseph L, Zablotska, Lydia B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Case-Control Studies Chernobyl Chernobyl Nuclear Accident Chornobyl Chronic lymphocytic leukemia Female Follow-Up Studies Gene mutation Genetic aspects Genome, Human - radiation effects Genomics Health aspects Humans Incidence Ionizing radiation Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology Leukemia, Lymphocytic, Chronic, B-Cell - etiology Male Middle Aged Mutation Neoplasms, Radiation-Induced - epidemiology Neoplasms, Radiation-Induced - etiology Occupational Exposure Prevalence Prognosis Radiation Dosage Radiation Exposure Risk factors Telomere Ukraine - epidemiology Young Adult
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Zusammenfassung:	Chronic lymphocytic leukemia (CLL) was the predominant leukemia in a recent study of Chornobyl cleanup workers from Ukraine exposed to radiation (UR-CLL). Radiation risks of CLL significantly increased with increasing bone marrow radiation doses. Current analysis aimed to clarify whether the increased risks were due to radiation or to genetic mutations in the Ukrainian population. A detailed characterization of the genomic landscape was performed in a unique sample of 16 UR-CLL patients and age- and sex-matched unexposed general population Ukrainian-CLL (UN-CLL) and Western-CLL (W-CLL) patients (n = 28 and 100, respectively). Mutations in telomere-maintenance pathway genes POT1 and ATM were more frequent in UR-CLL compared to UN-CLL and W-CLL (both p
ISSN:	1476-069X 1476-069X
DOI:	10.1186/s12940-018-0387-9