The Use of Biosensors to Explore the Potential of Probiotic Strains to Reduce the SOS Response and Mutagenesis in Bacteria

A model system based on the MG1655 (pRecA-lux) Lux-biosensor was used to evaluate the ability of the fermentates of eight probiotic strains to reduce the SOS response stimulated by ciprofloxacin in bacteria and mutagenesis mediated by it. Preliminary attempts to estimate the chemical nature of activ...

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Veröffentlicht in:	Biosensors (Basel) 2018-03, Vol.8 (1), p.25
Hauptverfasser:	Chistyakov, Vladimir Anatolievich, Prazdnova, Evgeniya Valer'evna, Mazanko, Maria Sergeevna, Bren, Anzhelica Borisovna
Format:	Artikel
Sprache:	eng
Schlagworte:	antimutagens Bacillus - metabolism Bacteria Biosensing Techniques - methods Biosensors Ciprofloxacin Ciprofloxacin - toxicity E coli E. coli biosensors Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli - metabolism Lactobacillus - metabolism Mutagenesis Mutagens - toxicity probiotic Probiotics Probiotics - metabolism Rec A Recombinases - genetics SOS response SOS Response (Genetics) Strains (organisms)
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Zusammenfassung:	A model system based on the MG1655 (pRecA-lux) Lux-biosensor was used to evaluate the ability of the fermentates of eight probiotic strains to reduce the SOS response stimulated by ciprofloxacin in bacteria and mutagenesis mediated by it. Preliminary attempts to estimate the chemical nature of active components of the fermentates were conducted.
ISSN:	2079-6374 2079-6374
DOI:	10.3390/bios8010025