Keratinocyte PIEZO1 modulates cutaneous mechanosensation

Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile information to sensory neurons. However, the specific mechanotransducers that enable keratinocytes to respond to mechanical stimulation are unknown. Here, we found that the mechanically-gated ion channel PIEZO1 is a ke...

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Veröffentlicht in:	eLife 2022-09, Vol.11
Hauptverfasser:	Mikesell, Alexander R, Isaeva, Olena, Moehring, Francie, Sadler, Katelyn E, Menzel, Anthony D, Stucky, Cheryl L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Biology Gene expression Ion Channels - genetics Ion Channels - metabolism keratinocyte Keratinocytes Keratinocytes - physiology Mechanical properties Mechanical stimuli Mechanotransduction Mechanotransduction, Cellular - physiology Mice Neurons Neuroscience pain Piezo1 Sensation Sensory neurons Sensory Receptor Cells - physiology Skin - metabolism Touch - physiology touch sensation
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Zusammenfassung:	Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile information to sensory neurons. However, the specific mechanotransducers that enable keratinocytes to respond to mechanical stimulation are unknown. Here, we found that the mechanically-gated ion channel PIEZO1 is a key keratinocyte mechanotransducer. Keratinocyte expression of PIEZO1 is critical for normal sensory afferent firing and behavioral responses to mechanical stimuli in mice.
ISSN:	2050-084X 2050-084X
DOI:	10.7554/eLife.65987