Comparative immunohistochemical characteristics of expression of estrogen receptors-alpha, progesterone receptors, p16, p53, Ki-67 and caspase 3 in invasive endometrial adenocarcinoma and normal proliferative endometrium

Endometrial cancer occupies the sixth place among newly diagnosed neoplasms in women. In late stage it has unpredictable prognosis. Immunohistichemical studies of the tumor are very important for prognosis of tumor course. The aim. To characterize the expression of the estrogen receptors-alpha, progesterone receptors, p53, p16, ki-67 and caspase 3 in the invasive endometrioid endometrial adenocarcinoma compared with the normal proliferative endometrium. Materials and methods. The uteruses of 56 women with the verified diagnosis of endometrial cancer (stage pT1-4MxNx) and biopsies of 30 women with normal proliferetive endometrium were analyzed. For this purpose, immunohistochemical and morphometrical studies were used. Results: It was established that level of expression of estrogen receptors-alpha was significantly lower in tumor glands and stroma compared with normal proliferative endometrium: the median was 6.0 (5.0; 7.0) points for tumor glands and 7.0 (6.0; 8.0) points for glands of normal proliferative endometrium(р