Serial Changes in Mannose-Binding Lectin in Patients with Sepsis

Serial Changes in Mannose-Binding Lectin in Patients with Sepsis

Background Mannose-binding lectin (MBL) deficiency leads to increased susceptibility to infection. We investigated whether serial changes in MBL levels are associated with the prognosis of patients diagnosed with septic shock, and correlated with cytokine levels. Methods We enrolled 131 patients wit...

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Veröffentlicht in:Tuberculosis and respiratory diseases 2017-12, Vol.81 (4), p.305-310
Hauptverfasser: Jin Won Huh, M.D., Ph.D., Kyuyoung Song, Ph.D., Hwa Jung Kim, M.D., Ph.D., Jung-Sun Yum, Ph.D., Sang-Bum Hong, M.D., Ph.D., Chae-Man Lim, M.D., Ph.D., Younsuck Koh, M.D., Ph.D.
Format: Artikel
Sprache:eng
Schlagworte:
cytokines
mannose-binding lectin
prognosis
septic
shock
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Zusammenfassung:Background Mannose-binding lectin (MBL) deficiency leads to increased susceptibility to infection. We investigated whether serial changes in MBL levels are associated with the prognosis of patients diagnosed with septic shock, and correlated with cytokine levels. Methods We enrolled 131 patients with septic shock in the study. We analyzed the serum samples for MBL and cytokine levels at baseline and 7 days later. Samples on day 7 were available in 73 patients. Results We divided the patients with septic shock into four groups according to serum MBL levels (
ISSN:1738-3536
2005-6184