Quantifying Carbohydrate-Deficient Transferrin in Serum

Alcohol abuse is a major public health problem with significant consequences for the society and economy. A biomarker commonly used for the analysis of alcohol abuse is serum CDT (carbohydrate-deficient transferrin). Very few conditions other than heavy alcohol consumption over a period of two to three weeks cause serum CDT to rise. Here we report a capillary electrophoresis method that is able to quantify CDT and the high resolution and reproducibility of the method make it possible to identify potential variants while avoiding false results. Zloupotreba alkohola jedan je od glavnih zdravstvenih problema sa značajnim posledicama za društvo i ekonomiju. Biomarkeri koji se obično koristi za analiziranje zloupotrebe alkohola je CDT u serumu. Vrlo malo stanja/poremećaja pored preterane konzumacije alkohola tokom perioda od dve do tri nedelje koje se može kvantifikovati CDT, dok visoka rezolucija i reproducibilnost metode omogućavaju identifikaciju potencijalnih varijanti bez opasnosti od lažno pozitivnih rezultata.