Impacts of diarrhea on the immune system, intestinal environment, and expression of PGRPs in New Zealand rabbits

Diarrhea is a syndrome of digestive disorders in young rabbits and may lead to secondary infections resulting in reduced immunity and higher mortality in baby rabbits, with serious impacts on rabbit farming. In this study, we investigated the effects of diarrhea on the health of baby rabbits in term...

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Veröffentlicht in:	PeerJ (San Francisco, CA) CA), 2017-11, Vol.5, p.e4100-e4100, Article e4100
Hauptverfasser:	Chen, Yang, Zhao, Bohao, Wu, Yuwei, Hu, Shuaishuai, Mu, Lin, Zhu, Cigen, Pan, Yulai, Wu, Xinsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Agricultural Science Alkaline phosphatase Ammonia Analysis Animal culture Animals Cecum Complications and side effects Cytokines Diarrhea Diseases Duodenum Genetics Health aspects Immune response Immunoglobulins Immunology Interleukin 6 Intestinal environment Intestine Laboratory animals Metabolism Microbiome Mucosal immunity New Zealand rabbit Nitrogen Peptidoglycan recognition proteins pH effects Proteins Rabbits rRNA 16S Transcription Tumor necrosis factor-TNF Tumor necrosis factor-α Urea Villus
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Zusammenfassung:	Diarrhea is a syndrome of digestive disorders in young rabbits and may lead to secondary infections resulting in reduced immunity and higher mortality in baby rabbits, with serious impacts on rabbit farming. In this study, we investigated the effects of diarrhea on the health of baby rabbits in terms of intestinal mucosal development, immune function, and intestinal microbial diversity. We found that the duodenal villus length and the villus/crypt ratio in rabbits with diarrhea were significantly reduced compared with those in healthy rabbits (
ISSN:	2167-8359 2167-8359
DOI:	10.7717/peerj.4100