Effects of Acute Exposure to Heat Stress on Immunological and Lipid Parameters in Rats

Background: Exposure to heat stress can result in lipid parameters alterations as well as immunological responses. This study was aimed to investigate these alterations and responses at different humidity and temperatures levels under controlled laboratory conditions in adult male Sprague–Dawley rats. Methods: A total 15 adult male Sprague–Dawley rats, weighing between 200 and 250 g, 10-11 weeks of age, were used in the evaluation. After one week, animals were randomly divided into three equal groups of 5 animals each. Reference group (group1) was housed in the cage under WBGT of 20(1) according to experimental design. Also, animals were subjected to mild (WBGT of 29 ( 1)) and hotter (WBGT of 33(1)) conditions (8 hr/day for one day) in the exposure chamber as group2 and group3, respectively. At the end of exposure to heat stress, blood samples were collected from the heart of rats and different parameters were determined. Results: Based on results, acute heat exposure significantly caused a decrease in serum IgG, IgM, IgA of rats in the case group compared to control group (P