Early biomarkers of neurodevelopmental disorders in preterm infants: protocol for a longitudinal cohort study

IntroductionPreterm (PT) infants are at high likelihood for poor neurodevelopmental outcomes, including autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD) and other neurodevelopmental disorders (NDDs), which could considerably impair the individuals’ functions throughout...

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Veröffentlicht in:	BMJ open 2023-06, Vol.13 (6), p.e070230-e070230
Hauptverfasser:	Zhao, Yilu, Liu, Yunfeng, Gao, Xuping, Wang, Dan, Wang, Ning, Xie, Rao, Tong, Xiaomei, He, Yong, Yang, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Autism Autism Spectrum Disorder - complications Biomarkers Brain research Child Child & adolescent psychiatry Cohort analysis Cohort Studies Congenital diseases Electroencephalography Hospitals Humans Infant Infant, Newborn Infant, Premature Longitudinal Studies Neurodevelopmental disorders Neurodevelopmental Disorders - epidemiology Neuropsychology paediatric radiology Paediatrics Pediatrics Premature babies Premature birth Prospective Studies psychiatry Spectrum analysis Teenagers
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Zusammenfassung:	IntroductionPreterm (PT) infants are at high likelihood for poor neurodevelopmental outcomes, including autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD) and other neurodevelopmental disorders (NDDs), which could considerably impair the individuals’ functions throughout their whole life. The current cohort study aims to investigate adverse outcomes, especially NDDs, in PT children, and the related early aberrant brain developmental biomarkers.Methods and analysisThis is a prospective cohort study in Beijing, China. We plan to recruit 400 PT infants born at
ISSN:	2044-6055 2044-6055
DOI:	10.1136/bmjopen-2022-070230