Image‐guided diagnosis and treatment of glioblastoma

Glioblastoma (GBM) is the most aggressive primary brain tumor with poor prognosis and high recurrence rate. The presence of the blood–brain barrier (BBB) prevents diagnostic and therapeutic drugs from penetrating and working in GBM. In traditional surgical treatment, it is difficult to completely distinguish the boundary between tumor and surrounding normal tissue, resulting in incomplete resection of tumor. Therefore, the diagnosis and treatment of GBM are very challenging. Several molecular probes and nanoprobes have been reported to successfully penetrate the BBB, selectively target and accumulate in GBM to achieve in situ imaging of brain tumors, thus achieving accurate diagnosis and treatment of orthotopic or non‐orthotopic GBM. This paper reviews the advances of molecular probes and nanoprobes in image‐guided diagnosis and treatment of GBM. The design principle, application, and advantages of each probe are enumerated in detail. Finally, the prospects and potential challenges of probes in the diagnosis and treatment of GBM are discussed with a view to further promote the study and application of novel imaging probes in GBM. In this review, the authors provide an overview of emerging theranostic agents based on molecular probes and nanoplatforms for GBM. This paper summarizes and discusses image‐guided diagnostic and therapeutic probes that can successfully penetrate the BBB, selectively target and accumulate in GBM to achieve in situ imaging of brain tumors, so as to achieve accurate diagnosis and treatment of orthotopic or non‐orthotopic GBM.