Factors associated with high-risk low-level viremia leading to virologic failure: 16-year retrospective study of a Chinese antiretroviral therapy cohort

Low level viremia (LLV) often occurs during antiretroviral therapy (ART) against HIV-1. However, whether LLV increases the risk of virologic failure (VF) is controversial because of the non-uniform definitions of LLV and VF. A long-term first line regimen ART cohort from 2002 to 2018 from Shenyang,...

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Veröffentlicht in:BMC infectious diseases 2020-02, Vol.20 (1), p.147-147, Article 147
Hauptverfasser: Zhang, Tong, Ding, Haibo, An, Minghui, Wang, Xiaonan, Tian, Wen, Zhao, Bin, Han, Xiaoxu
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Sprache:eng
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Zusammenfassung:Low level viremia (LLV) often occurs during antiretroviral therapy (ART) against HIV-1. However, whether LLV increases the risk of virologic failure (VF) is controversial because of the non-uniform definitions of LLV and VF. A long-term first line regimen ART cohort from 2002 to 2018 from Shenyang, northeast China, was retrospectively studied. All participants were followed up every 3 to 6 months to evaluate the treatment effect. The high-risk LLV subgroups leading to VF (with strict standards) were explored with Cox proportional hazards model and linear mixed-effect model. The association factors of high-risk LLV were further explored using multivariate logistic regression analyses. A total of 2155 HIV-1 infected participants were included; of these, 38.7% showed LLV. Both high level LLV (HLLV) and any other level LLV coupled with high level blip (HLB) showed higher risk of VF (hazards ratios, HR  = 5.93, and HR  = 2.84, p 
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-020-4837-y