N -Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry

N -Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry

The acylation of amines has always attracted a deep interest as a synthetic route due to its high versatility in organic chemistry and biochemical processes. The purpose of this article is to present a mechanochemical acylation procedure based on the use of acyl-saccharin derivatives, namely -formyl...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2022-08, Vol.27 (17), p.5450
Hauptverfasser: Cuccu, Federico, Basoccu, Francesco, Fattuoni, Claudia, Porcheddu, Andrea
Format: Artikel
Sprache:eng
Schlagworte:
Acylation
Amines
Analgesics
ball milling
formamides
green chemistry
mechanochemistry
Organic chemistry
Pharmaceuticals
Saccharin
Solvents
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The acylation of amines has always attracted a deep interest as a synthetic route due to its high versatility in organic chemistry and biochemical processes. The purpose of this article is to present a mechanochemical acylation procedure based on the use of acyl-saccharin derivatives, namely -formylsaccharin, -acetylsaccharin, and -propionylsaccharin. This protocol furnishes a valuable solvent-free alternative to the existing processes and aims to be highly beneficial in multi-step procedures due to its rapid and user-friendly workup.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27175450