Hereditary persistence of fetal hemoglobin

Hereditary persistence of fetal hemoglobin

Hereditary persistence of fetal hemoglobin (HPFH) is a benign condition in which significant fetal hemoglobin production continues well into adulthood, disregarding the normal shutoff point after which only adult-type hemoglobin should be produced. The percentage of incorrect expression might be as...

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Veröffentlicht in:Asian journal of transfusion science 2020-07, Vol.14 (2), p.185-186
Hauptverfasser: Sharma, Dharmesh, Singhal, Sachin, Woike, Poonam, Rai, Sunita, Yadav, Mahesh, Gaur, Rajesh
Format: Artikel
Sprache:eng
Schlagworte:
Case Report
Case reports
Child development
Fetuses
Genetics
Glycosylated hemoglobin
Hemoglobin
hereditary persistence of fetal hemoglobin
heterozygotes
homozygotes
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Zusammenfassung:Hereditary persistence of fetal hemoglobin (HPFH) is a benign condition in which significant fetal hemoglobin production continues well into adulthood, disregarding the normal shutoff point after which only adult-type hemoglobin should be produced. The percentage of incorrect expression might be as low as 10%-15% or as high as 100% of the total hemoglobin, usually higher in homozygotes than in heterozygotes. The present case is a typical example of homozygous HPFH.
ISSN:0973-6247
1998-3565
DOI:10.4103/ajts.AJTS_71_16