Mesoporous Silica Nanoparticles for Drug Delivery: Current Insights

This manuscript reviews the recent progress on mesoporous silica nanoparticles as drug delivery systems. Their intrinsic structural, textural and chemical features permit to design versatile multifunctional nanosystems with the capability to target the diseased tissue and release the cargo on demand...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2017-12, Vol.23 (1), p.47
Hauptverfasser:	Vallet-Regí, María, Colilla, Montserrat, Izquierdo-Barba, Isabel, Manzano, Miguel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals benefits and downsides biosafety Body Fluids clinical translation Drug delivery Drug Delivery Systems External stimuli Humans in vitro degradation mesoporous silica nanoparticles multifunctional nanosystem Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure Porosity Porous materials Review selective targeting Silica Silicon Dioxide - chemistry stimuli-responsive drug delivery Therapeutic applications
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Beschreibung
Zusammenfassung:	This manuscript reviews the recent progress on mesoporous silica nanoparticles as drug delivery systems. Their intrinsic structural, textural and chemical features permit to design versatile multifunctional nanosystems with the capability to target the diseased tissue and release the cargo on demand upon exposition to internal or external stimuli. The degradation rate of these nanocarriers in diverse physiological fluids is overviewed obeying their significance for their potential translation towards clinical applications. To conclude, the balance between the benefits and downsides of this revolutionary nanotechnological tool is also discussed.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules23010047