Highly Pathogenic Clone of Shiga Toxin-Producing Escherichia coli O157:H7, England and Wales

Highly Pathogenic Clone of Shiga Toxin-Producing Escherichia coli O157:H7, England and Wales

We used whole-genome sequencing to investigate the evolutionary context of an emerging highly pathogenic strain of Shiga toxin-producing Escherichia coli (STEC) O157:H7 in England and Wales. A timed phylogeny of sublineage IIb revealed that the emerging clone evolved from a STEC O157:H7 stx-negative...

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Veröffentlicht in:Emerging infectious diseases 2018-12, Vol.24 (12), p.2303-2308
Hauptverfasser: Byrne, Lisa, Dallman, Timothy J, Adams, Natalie, Mikhail, Amy F W, McCarthy, Noel, Jenkins, Claire
Format: Artikel
Sprache:eng
Schlagworte:
bacteria
DNA sequencing
England - epidemiology
enteric infections
Escherichia coli
Escherichia coli Infections - diagnosis
Escherichia coli Infections - epidemiology
Escherichia coli Infections - microbiology
Escherichia coli O157 - classification
Escherichia coli O157 - pathogenicity
Escherichia coli O157 - virology
evolution
Evolution, Molecular
Female
Genome, Bacterial
Genomics - methods
Highly Pathogenic Clone of Shiga Toxin–producing
Humans
Male
Phylogeny
Polymorphism, Single Nucleotide
Severity of Illness Index
Shiga toxin–producing Escherichia coli
Signs and symptoms
virulence
Wales - epidemiology
whole-genome sequencing
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Beschreibung
Zusammenfassung:We used whole-genome sequencing to investigate the evolutionary context of an emerging highly pathogenic strain of Shiga toxin-producing Escherichia coli (STEC) O157:H7 in England and Wales. A timed phylogeny of sublineage IIb revealed that the emerging clone evolved from a STEC O157:H7 stx-negative ancestor ≈10 years ago after acquisition of a bacteriophage encoding Shiga toxin (stx) 2a, which in turn had evolved from a stx2c progenitor ≈20 years ago. Infection with the stx2a clone was a significant risk factor for bloody diarrhea (OR 4.61, 95% CI 2.24-9.48; p
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2412.180409