Alpha-Synuclein and Cognitive Decline in Parkinson Disease

Parkinson disease (PD) is the second most common neurodegenerative disorder in elderly people. It is characterized by the aggregation of misfolded alpha-synuclein throughout the nervous system. Aside from cardinal motor symptoms, cognitive impairment is one of the most disabling non-motor symptoms t...

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Veröffentlicht in:Life (Basel, Switzerland) Switzerland), 2021-11, Vol.11 (11), p.1239
Hauptverfasser: Fan, Tian-Sin, Liu, Sam Chi-Hao, Wu, Ruey-Meei
Format: Artikel
Sprache:eng
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Zusammenfassung:Parkinson disease (PD) is the second most common neurodegenerative disorder in elderly people. It is characterized by the aggregation of misfolded alpha-synuclein throughout the nervous system. Aside from cardinal motor symptoms, cognitive impairment is one of the most disabling non-motor symptoms that occurs during the progression of the disease. The accumulation and spreading of alpha-synuclein pathology from the brainstem to limbic and neocortical structures is correlated with emerging cognitive decline in PD. This review summarizes the genetic and pathophysiologic relationship between alpha-synuclein and cognitive impairment in PD, together with potential areas of biomarker advancement.
ISSN:2075-1729
2075-1729
DOI:10.3390/life11111239