Clinical and genetic drivers of oligo-metastatic disease in colon cancer

•Approximately 10 % of patients with metastatic colon cancer exhibit oligo-metastatic disease (OMD).•Identifying clinical and molecular predictors of OMD is essential for improving the treatment of metastatic colon cancer.•OMD is more commonly associated with male gender and involvement of a single...

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Veröffentlicht in:Neoplasia (New York, N.Y.) N.Y.), 2025-02, Vol.60, p.101111, Article 101111
Hauptverfasser: Ottaiano, Alessandro, Santorsola, Mariachiara, Sirica, Roberto, Mauro, Annabella Di, Di Carlo, Antonella, Ianniello, Monica, Sabbatino, Francesco, Castiello, Rosa, Peschio, Francesca Del, Cascella, Marco, Perri, Francesco, Capuozzo, Maurizio, Martucci, Nicola, Mercadante, Edoardo, Borzillo, Valentina, Di Franco, Rossella, Izzo, Francesco, Granata, Vincenza, Picone, Carmine, Petrillo, Antonella, Berretta, Massimiliano, Stilo, Salvatore, Tarotto, Luca, Carratù, Anna Chiara, Ferrara, Gerardo, Tathode, Madhura, Cossu, Alessia Maria, Bocchetti, Marco, Caraglia, Michele, Nasti, Guglielmo, Savarese, Giovanni
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Sprache:eng
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Zusammenfassung:•Approximately 10 % of patients with metastatic colon cancer exhibit oligo-metastatic disease (OMD).•Identifying clinical and molecular predictors of OMD is essential for improving the treatment of metastatic colon cancer.•OMD is more commonly associated with male gender and involvement of a single organ.•OMD is characterized by lower rates of BRAF p.V600E and KRAS mutations and a higher tumor mutational burden. Oligo-metastatic disease (OMD) in colon cancer patients exhibits distinct clinical behavior compared to poly-metastatic disease (PMD), with a more responsive and indolent course. This study aims to identify clinical and biological factors uniquely associated with oligo-metastatic behavior. Metastatic colon cancer patients from an academic center underwent genetic characterization. OMD was defined as ≤3 lesions per organ, each with a total diameter 70 vs.
ISSN:1476-5586
1476-5586
DOI:10.1016/j.neo.2024.101111