Cellular internalization and antioxidant activity of cerium oxide nanoparticles in human monocytic leukemia cells

Overproduction of free radicals contributes to oxidative stress and inflammation leading to various disease conditions. Cerium oxide nanoparticles (nanoceria) have been shown to scavenge free radicals and have the potential for being used as a therapeutic agent in disease conditions. Therefore, in t...

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Veröffentlicht in:	International journal of nanomedicine 2018, Vol.13 (T-NANO 2014 Abstracts), p.39-41
Hauptverfasser:	Patel, Pal, Kansara, Krupa, Singh, Ragini, Shukla, Ritesh K, Singh, Sanjay, Dhawan, Alok, Kumar, Ashutosh
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidant Antioxidants - pharmacology Antioxidants - therapeutic use Cell Death - drug effects Cell Line, Tumor Cerium - pharmacology Cerium - therapeutic use Endocytosis Free radicals Humans Inflammation Leukemia - drug therapy Microscopy, Fluorescence Monocytes - pathology Nanoceria Nanoparticles - chemistry Oxidative Stress - drug effects Reactive Oxygen Species Reactive Oxygen Species - metabolism Short Report Spectrophotometry, Ultraviolet
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Zusammenfassung:	Overproduction of free radicals contributes to oxidative stress and inflammation leading to various disease conditions. Cerium oxide nanoparticles (nanoceria) have been shown to scavenge free radicals and have the potential for being used as a therapeutic agent in disease conditions. Therefore, in the present study, human monocytic leukemia cells (THP-1) were used as a model to evaluate the uptake and free radical scavenging activity of nanoceria. Our data showed a significant (
ISSN:	1178-2013 1176-9114 1178-2013
DOI:	10.2147/IJN.S124996