Early postnatal hypoferremia in low birthweight and preterm babies: A prospective cohort study in hospital-delivered Gambian neonates

Neonates, particularly those born preterm (PTB) and with low birthweight (LBW), are especially susceptible to bacterial and fungal infections that cause an estimated 225,000 deaths annually. Iron is a vital nutrient for the most common organisms causing septicaemia. Full-term babies elicit an immedi...

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Veröffentlicht in:	EBioMedicine 2020-02, Vol.52, p.102613-102613, Article 102613
Hauptverfasser:	Cross, James H., Jarjou, Ousman, Mohammed, Nuredin Ibrahim, Rayment Gomez, Santiago, Touray, Bubacarr J.B, Prentice, Andrew M., Cerami, Carla
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Birth Weight Case-Control Studies CRP Disease Resistance Fetal Blood General & Internal Medicine Gestational Age Hepcidin Humans Infant Infant, Low Birth Weight Infant, Newborn Infant, Premature Iron Iron - blood Life Sciences & Biomedicine Low birthweight Male Medicine, General & Internal Medicine, Research & Experimental Neonates Nutritional immunity Prematurity Research & Experimental Medicine Research paper Science & Technology Septicaemia Sub-Saharan Africa Time Factors Transferrin saturation
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Zusammenfassung:	Neonates, particularly those born preterm (PTB) and with low birthweight (LBW), are especially susceptible to bacterial and fungal infections that cause an estimated 225,000 deaths annually. Iron is a vital nutrient for the most common organisms causing septicaemia. Full-term babies elicit an immediate postnatal hypoferremia assumed to have evolved as an innate defence. We tested whether PTB and LBW babies are capable of the same response. We conducted an observational study of 152 babies who were either PTB (born ≥32 to
ISSN:	2352-3964 2352-3964
DOI:	10.1016/j.ebiom.2019.102613