Features of Parameters of Glial Protein S100 Amount and the Level of Total Nitric Oxide Metabolites in the Blood of Extremely Preterm Infants with Perinatal Hypoxic Brain Damage

The frequency of low birth-weight children with extremely low and very low birth weight infants over the past decade has remained stable and in the developed world is 5–12 % of the total number of births. Frequency of perinatal brain lesions at them is 50–80 %. In this regard, the definition of the features of the content of specific proteins of brain tissue and total nitric oxide metabolites in the blood of extremely preterm children with perinatal brain lesions is an important task. A comprehensive clinical and laboratory examination of 92 children in the dynamics of the first year of life has been carried out. Study group comprised 70 extremely preterm children with perinatal hypoxic brain damage and gestational age at birth 25–32 weeks, the comparison group — 22 healthy full-term in infants who did not have abnormalities in the nervous system. The study established contingency changes of the amount of protein S100 and total nitric oxide metabolites in the blood of extremely preterm children with various severity of perinatal brain damage and gestational age at birth. Diagnostic value of the studied glial protein in the assessment of the severity of cerebral ischemia in the early neonatal period has been sustantiated.