Expression of proteins related to autotaxin-lysophosphatidate signaling in thyroid tumors

We aimed to investigate the expression of proteins related with autotaxin (ATX)-lysophosphatidate (LPA) signaling and the clinical implications in primary and metastatic thyroid tumors. We constructed tissue microarrays with 545 primary thyroid tumors [338 papillary thyroid carcinoma (PTC), 111 foll...

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Veröffentlicht in:	Journal of translational medicine 2019-08, Vol.17 (1), p.288-288, Article 288
Hauptverfasser:	Shin, Eunah, Koo, Ja Seung
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Autotaxin Breast cancer Cancer metastasis Carcinoma Cell adhesion & migration Development and progression Gene expression Gene mutation Genetic aspects Glycoproteins Hospitals Lysophosphatidate Medical prognosis Metastases Metastasis Mutation Papillary thyroid carcinoma Pathology Proteins Signaling peptides and proteins Statistical analysis Thyroid Thyroid cancer Thyroid diseases Tumor Tumors
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Zusammenfassung:	We aimed to investigate the expression of proteins related with autotaxin (ATX)-lysophosphatidate (LPA) signaling and the clinical implications in primary and metastatic thyroid tumors. We constructed tissue microarrays with 545 primary thyroid tumors [338 papillary thyroid carcinoma (PTC), 111 follicular carcinoma (FC), 69 medullary carcinoma (MC), 23 poorly differentiated carcinoma (PDC), and four anaplastic carcinoma (AC)]. Immunohistochemical stains for proteins related to ATX-LPA signaling (e.g., ATX, LPA1, LPA2, and LPA3) were performed. The expression of ATX was highest in MC, while the LPA1 expression was higher in PDC and AC, and the expression of LPA2 and LPA3 was highest in PTC (p
ISSN:	1479-5876 1479-5876
DOI:	10.1186/s12967-019-2028-7