Design, synthesis and anticancer evaluation of various aryl amide derivatives of thiazole-benzothiazole-pyrimidines

[Display omitted] We have developed a new series of various aryl amide derivatives of thiazole-benzothaizole-pyrimidines (13a-j). Their chemical structures were characterized by 1HNMR, 13CNMR and mass spectral data. Further, in vitro anticancer properties of newly developed compounds 13a-j were investigated against four human cancer cell lines including MCF-7 (breast cancer), A549 (lung cancer), Colo-205 (colon cancer) & A2780 (ovarian cancer) by employing the MTT assay, and were compared with etoposide used as a standard reference. Most of the tested compounds displayed moderate to good anticancer activities compared to etoposide. The in vitro assay results indicated that compounds 13a, 13b, 13c and 13d possessed more potent activity as compared with the standard. One of the compounds, like 13a displayed superior anticancer activity.