The influence of intrathecal injection of methotrexate and dexamethasone on neuropsychiatric systemic lupus erythematosus (NPSLE): a retrospective cohort study of 386 patients with NPSLE

Neuropsychiatric involvement is one of the major concerns in systemic lupus erythematosus (SLE). The therapeutic effect of intrathecal treatment of methotrexate and dexamethasone has been investigated in some exploratory studies, but its influence on the long-term prognosis of neuropsychiatric SLE (...

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Veröffentlicht in:	Arthritis research & therapy 2023-03, Vol.25 (1), p.50-50, Article 50
Hauptverfasser:	Nie, Yuxue, Sun, Boyuan, He, Xin, Zheng, Minmin, Wu, Di, Yang, Yunjiao, Zhang, Li, Bai, Wei, Jiang, Nan, Qiao, Lin, Huang, Can, Zhou, Shuang, Zhou, Jiaxin, Peng, Linyi, Niu, Jingwen, Li, Mengtao, Zhao, Yan, Zeng, Xiaofeng, Wang, Li, Zhang, Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Arthritis Blood Care and treatment Classification Clinical outcomes Cohort analysis Dexamethasone Diagnosis Diagnostic tests Disease Dosage and administration Female Health aspects Hospital patients Hospitalization Humans Immunomodulators Injections, Spinal Laboratories Lupus Lupus erythematosus Lupus Erythematosus, Systemic - complications Lupus Vasculitis, Central Nervous System - complications Lupus Vasculitis, Central Nervous System - drug therapy Male Medical records Methotrexate Methotrexate - therapeutic use Nervous system Neurologic manifestations Patients Recurrence Retrospective Studies Rheumatology Steroids Systemic Systemic lupus erythematosus Therapy Young Adult
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Zusammenfassung:	Neuropsychiatric involvement is one of the major concerns in systemic lupus erythematosus (SLE). The therapeutic effect of intrathecal treatment of methotrexate and dexamethasone has been investigated in some exploratory studies, but its influence on the long-term prognosis of neuropsychiatric SLE (NPSLE) remains unknown. This was a propensity score-matched retrospective study. Outcomes at discharge and time free from NPSLE relapse or death were evaluated by multivariate logistic regression, survival analysis, and Cox regression as appropriate. Among 386 hospitalized patients with NPSLE, the median [IQR] age was 30.0 [23.0-40.0] years, and 342 patients (88.4%) were female. Of those, 194 patients received intrathecal treatment. Patients in the intrathecal treatment group had higher Systemic Lupus Erythematosus Disease Activity Index 2000 scores (median 17 vs. 14 points, IQR 12-22 vs. 10-19 points, P
ISSN:	1478-6362 1478-6354 1478-6362
DOI:	10.1186/s13075-023-03030-w