Mitochondrial stroke-like episodes: The search for new therapies

A mitochondrial stroke-like event is an evolving subacute neurological syndrome linked to seizure activity and focal metabolic brain derangement in a genetically determined mitochondrial disorder. The acronym “MELAS” (mitochondrial encephalopathy associated with lactic acidosis and stroke-like lesio...

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Veröffentlicht in:Pharmacological research 2022-06, Vol.180, p.106228-106228, Article 106228
Hauptverfasser: Orsucci, Daniele, Caldarazzo Ienco, Elena, Montano, Vincenzo, Siciliano, Gabriele, Mancuso, Michelangelo
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Sprache:eng
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Zusammenfassung:A mitochondrial stroke-like event is an evolving subacute neurological syndrome linked to seizure activity and focal metabolic brain derangement in a genetically determined mitochondrial disorder. The acronym “MELAS” (mitochondrial encephalopathy associated with lactic acidosis and stroke-like lesions) identifies subjects with molecular, biochemical and/or histological evidence of mitochondrial disorder who experience stroke-like lesions. MELAS is a rare inherited mitochondrial disease linked to severe multiorgan involvement and stress-induced episodes of metabolic decompensation and lactic acidosis. Unfortunately, there are no etiopathogenetic therapies for stroke-like episodes to date, and the treatment is mainly based on anti-epileptic drugs and supportive therapies. This perspective opinion article discusses the current care standards for MELAS patients and revises current and innovative emerging therapies for mitochondrial stroke-like episodes. [Display omitted]
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2022.106228