ALLELIC POLYMORPHISM OF IFNγ GENE IN PATIENTS WITH PULMONARY TUBERCULOSIS

ALLELIC POLYMORPHISM OF IFNγ GENE IN PATIENTS WITH PULMONARY TUBERCULOSIS

In present work, some immunogenetic aspects of pulmonary tuberculosis were studied, using modern techniques from molecular genetics and immunology. It is shown that carriage of Т allele and homozygous TT genotype in +874А/Т IFNγ gene polymorphism comprise a immunogenetic factor which correlated with...

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Veröffentlicht in:Medit͡s︡inskai͡a︡ immunologii͡a 2014-07, Vol.12 (3), p.259-264
Hauptverfasser: Nikulina, E. L., Naslednikova, I. O., Urazova, O. I., Voronkova, O. V., Novitsky, V. V., Nekrasov, E. V., Filiniuk, O. V., Churina, E. G., Mikheyeva, K. O., Hasanova, R. R., Serebryakova, V. A., Sukhalentseva, N. A.
Format: Artikel
Sprache:eng
Schlagworte:
gene polymorphism
interferon-γ
tuberculosis
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Zusammenfassung:In present work, some immunogenetic aspects of pulmonary tuberculosis were studied, using modern techniques from molecular genetics and immunology. It is shown that carriage of Т allele and homozygous TT genotype in +874А/Т IFNγ gene polymorphism comprise a immunogenetic factor which correlated with a protective effect, regarding a susceptibility to pulmonary tuberculosis. Predisposition for tuberculosis infection is associated with A allele of this gene, as well as with АА and АТ genotypes of +874A/T IFNγ gene. Clinical evolution of pulmonary tuberculosis is accompanied by increase in IFNγ production.
ISSN:1563-0625
2313-741X
DOI:10.15789/1563-0625-2010-3-259-264