Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass ( n = 28,330) measured using dual energy X-ray absorpt...

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Veröffentlicht in:	Nature communications 2017-07, Vol.8 (1), p.80-13, Article 80
Hauptverfasser:	Hsu, Yi-Hsiang, Stolk, Lisette, Livshits, Gregory, Luan, Jian’an, Malkin, Ida, Ried, Janina S., Smith, Albert V., Vandenput, Liesbeth, Hua Zhao, Jing, Åkesson, Kristina, Barroso, Inês, Bertram, Lars, Biffar, Rainer, Boehnke, Michael, Buchman, Aron S., Cauley, Jane A., Cederberg, Henna, Chen, Zhao, Cho, Nam H., De Jager, Philip L., Enneman, Anke W., Estrada, Karol, Fu, Mao, Gieger, Christian, Girke, Thomas, Glazer, Nicole L., Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L., Hayward, Caroline, Hoffman, Eric P., Homuth, Georg, Hubbard, Alan, Huffman, Kim M., Husted, Lise B., Illig, Thomas, Ingelsson, Erik, Jula, Antti, Karlsson, Magnus, Kilpeläinen, Tuomas O., Klopp, Norman, Koistinen, Heikki A., Kritchevsky, Stephen, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L., Lee, Jong-Young, Lewis, Joshua R., Lind, Lars, Liu, Yongmei, Liu, Tian, Liu, Youfang, Luben, Robert N., Melhus, Håkan, Mellström, Dan, Michaëlsson, Karl, Mitchell, Braxton D., Morris, Andrew P., Mosekilde, Leif, Newman, Anne, O’Connell, Jeffrey R., Oostra, Ben A., Palotie, Aarno, Parker, Stephen C. J., Perola, Markus, Polasek, Ozren, Räikkönen, Katri, Ralston, Stuart H., Ripatti, Samuli, Rotter, Jerome I., Schipf, Sabine, Shen, Jian, Soo Shin, Chan, Soranzo, Nicole, Stančáková, Alena, Steinhagen-Thiessen, Elisabeth, Styrkarsdottir, Unnur, Tan, Sian-Tsung, Tarnopolsky, Mark A., Thorsteinsdottir, Unnur, Tranah, Gregory J., Tuomilehto, Jaakko, van Schoor, Natasja M., Weedon, Michael N., Welch, Ryan, Widen, Elisabeth, Wilson, James F., Wright, Nicole C., Xie, Weijia, Yu, Lei, Döring, Angela, van Duijn, Cornelia M., Econs, Michael J., Gudnason, Vilmundur, Psaty, Bruce M., Spector, Timothy D., Ossowski, Vicky, Harris, Tamara B., Ohlsson, Claes
Format:	Artikel
Sprache:	eng
Schlagworte:	17-Hydroxysteroid Dehydrogenases - genetics 631/208/199 631/208/205/2138 692/53/2423 ADAMTS Proteins - genetics Aldehyde Oxidoreductases - genetics Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics Basic Medicine Body Composition BONE-MINERAL DENSITY CS Onderwijsinstituut Extracellular Matrix Proteins - genetics Gastroenterologi och hepatologi Gastroenterology and Hepatology GENE-EXPRESSION Genome-Wide Association Study HUMAN HEIGHT Humanities and Social Sciences Humans Insulin Receptor Substrate Proteins - genetics INSULIN-RESISTANCE Medical and Health Sciences Medical Genetics Medicin och hälsovetenskap Medicinsk genetik Medicinska och farmaceutiska grundvetenskaper multidisciplinary OBESITY Onderwijsinstituut Phenotype PHYSICAL-DISABILITY Polymorphism, Single Nucleotide Quantitative Trait Loci Regulatory Elements, Transcriptional SARCOPENIA Science Science (multidisciplinary) SKELETAL-MUSCLE MASS Thinness - genetics UNITED-STATES VARIANTS Versicans - genetics
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Zusammenfassung:	Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass ( n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide ( p
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-017-00031-7