Osteopontin in oral squamous cell carcinoma: A multifaceted player in tumor development and prognosis

Osteopontin in oral squamous cell carcinoma: A multifaceted player in tumor development and prognosis

•Osteopontin (OPN) is a multifunctional protein linked to inflammation, bone metabolism, and cancer pathogenesis.•OPN plays pivotal roles in oral squamous cell carcinoma (OSCC) development and progression.•Elevated OPN levels correlate with advanced tumor grades and aggressive behavior in OSCC.•OPN...

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Veröffentlicht in:Oral oncology reports 2024-06, Vol.10, p.100452, Article 100452
Hauptverfasser: Suryawanshi, Hema, Hande, Alka, Palle, Harshita Yadav, Veeraraghavan, Vishnu Priya, Sahu, Manisha, Patil, Santosh R.
Format: Artikel
Sprache:eng
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Zusammenfassung:•Osteopontin (OPN) is a multifunctional protein linked to inflammation, bone metabolism, and cancer pathogenesis.•OPN plays pivotal roles in oral squamous cell carcinoma (OSCC) development and progression.•Elevated OPN levels correlate with advanced tumor grades and aggressive behavior in OSCC.•OPN shows promise as a diagnostic marker and predictor of recurrence in OSCC.•Research suggests OPN assessment may guide treatment decisions and improve patient management in OSCC.
ISSN:2772-9060
2772-9060
DOI:10.1016/j.oor.2024.100452