Editorial: Engineered neuromodulation approaches to treat neurological disorders

Robust seizure control was reportedly attained during treatment and in the ensuing months. [...]changes in EEG biomarkers provided evidence of rTMS effects on cortical excitability while bringing about novel insights into its mechanisms of action, including those related to brain connectivity and neural plasticity. [...]Dell'Italia et al. contributed a comprehensive review on Low Intensity Focused Ultrasound (LIFU), a novel neuromodulation technique that has attracted a lot of attention recently. [...]this collection brings up key messages to the field, including the undisputed value of detailed theoretical in silico studies (Khatoun et al.), the importance of investigating mechanisms of action in different levels of brain organization (Dell'Italia et al.; Yuan et al.), including neural plasticity-related mechanisms (Starnes et al.; Yuan et al.), and the validity of thinking outside the box in the search of novel forms of modulating the brain activity (Khatoun et al.; Dell'Italia et al.; Zhao et al.).