The effect of Aspalathus linearis (Burm.f.) R.Dahlgren and its compounds on tyrosinase and melanogenesis

The effect of Aspalathus linearis (Burm.f.) R.Dahlgren and its compounds on tyrosinase and melanogenesis

Pigmentation, a process controlled by melanogenesis, plays a vital role in protecting the skin against harmful ultraviolet rays. The level of protection is compromised in case of hypopigmentation. This study aimed to evaluate an Aspalathus linearis extract, fractions and phytoconstituents, for their...

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Veröffentlicht in:Scientific reports 2021-03, Vol.11 (1), p.7020-7020, Article 7020
Hauptverfasser: Blom van Staden, Analike, Oosthuizen, Carel B., Lall, Namrita
Format: Artikel
Sprache:eng
Schlagworte:
631/114
631/80
631/92/349
631/92/607
Aspalathus linearis
Catechin
Cell viability
Enzymes
Humanities and Social Sciences
Melanin
multidisciplinary
Pigmentation
Science
Science (multidisciplinary)
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Zusammenfassung:Pigmentation, a process controlled by melanogenesis, plays a vital role in protecting the skin against harmful ultraviolet rays. The level of protection is compromised in case of hypopigmentation. This study aimed to evaluate an Aspalathus linearis extract, fractions and phytoconstituents, for their efficacy on melanogenesis stimulation. Fifteen compounds were kinetically assessed against tyrosinase; the rate-limiting enzyme of melanogenesis. Aspalathin and catechin significantly ( p value 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-86410-z