Effects of YM087 and VPA985 on the T237M mutant receptor functionality in nephrogenic diabetes insipidus

Effects of YM087 and VPA985 on the T237M mutant receptor functionality in nephrogenic diabetes insipidus

Mutations detected in the AVPR2 gene (arginine vasopressin type 2 receptor) are known to cause nephrogenic diabetes insipidus (NDI). Several pharmacological chaperones (PCs) target misfolded AVPR2 proteins and rescue them from the quality control system of the cell. In this study, we investigated th...

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Veröffentlicht in:Türk biyokimya dergisi 2024-10, Vol.49 (5), p.685-690
Hauptverfasser: Avcu, Elif Merve, Erdem Tuncdemir, Beril, Saglar Ozer, Emel
Format: Artikel
Sprache:eng
Schlagworte:
avpr2
nephrogenic diabetes insipidus
pharmacological chaperone
VPA985
YM087
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Zusammenfassung:Mutations detected in the AVPR2 gene (arginine vasopressin type 2 receptor) are known to cause nephrogenic diabetes insipidus (NDI). Several pharmacological chaperones (PCs) target misfolded AVPR2 proteins and rescue them from the quality control system of the cell. In this study, we investigated the effect of YM087 and VPA985, which are PCs, on T273M-AVPR2 mutant that are known to cause NDI.
ISSN:1303-829X
1303-829X
DOI:10.1515/tjb-2024-0024