The blood oxygen level dependent (BOLD) effect of in-vitro myoglobin and hemoglobin

The blood oxygen level dependent (BOLD) effect of in-vitro myoglobin and hemoglobin

The presence of deoxygenated hemoglobin (Hb) results in a drop in T2 and T2* in magnetic resonance imaging (MRI), known as the blood oxygenation level-dependent (BOLD-)effect. The purpose of this study was to investigate if deoxygenated myoglobin (Mb) exerts a BOLD-like effect. Equine Met-Mb powder...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Scientific reports 2021-06, Vol.11 (1), p.11464-11464, Article 11464
Hauptverfasser: Guensch, Dominik P., Michel, Matthias C., Huettenmoser, Stefan P., Jung, Bernd, Gulac, Patrik, Segiser, Adrian, Longnus, Sarah L., Fischer, Kady
Format: Artikel
Sprache:eng
Schlagworte:
692/308/2778
692/4019
692/700/1421/1628
Blood
Chemical reduction
Functional magnetic resonance imaging
Hemoglobin
Humanities and Social Sciences
Mapping
multidisciplinary
Myoglobins
Oxygenation
Science
Science (multidisciplinary)
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The presence of deoxygenated hemoglobin (Hb) results in a drop in T2 and T2* in magnetic resonance imaging (MRI), known as the blood oxygenation level-dependent (BOLD-)effect. The purpose of this study was to investigate if deoxygenated myoglobin (Mb) exerts a BOLD-like effect. Equine Met-Mb powder was dissolved and converted to oxygenated Mb. T1, T2, T2*-maps and BOLD-bSSFP images at 3Tesla were used to scan 22 Mb samples and 12 Hb samples at room air, deoxygenation, reoxygenation and after chemical reduction. In Mb, T2 and T2* mapping showed a significant decrease after deoxygenation (− 25% and − 12%, p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-90908-x