Collagen-coated superparamagnetic iron oxide nanoparticles as a sustainable catalyst for spirooxindole synthesis

In this work, a novel magnetic organic–inorganic hybrid catalyst was fabricated by encapsulating magnetite@silica (Fe 3 O 4 @SiO 2 ) nanoparticles with Isinglass protein collagen (IGPC) using epichlorohydrin (ECH) as a crosslinking agent. Characterization studies of the prepared particles were accom...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Scientific reports 2022-04, Vol.12 (1), p.6104-6104, Article 6104
Hauptverfasser: Azarnier, Shima Ghanbari, Esmkhani, Maryam, Dolatkhah, Zahra, Javanshir, Shahrzad
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:In this work, a novel magnetic organic–inorganic hybrid catalyst was fabricated by encapsulating magnetite@silica (Fe 3 O 4 @SiO 2 ) nanoparticles with Isinglass protein collagen (IGPC) using epichlorohydrin (ECH) as a crosslinking agent. Characterization studies of the prepared particles were accomplished by various analytical techniques specifically, Fourier transform infrared (FTIR) analysis, scanning electron microscopy (SEM), transmission electron microscopy (TEM), vibrating sample magnetometry (VSM), energy-dispersive X-ray spectroscopy (EDS), X-ray powder diffraction (XRD), thermogravimetric analysis (TGA), and Brunauer−Emmett−Teller (BET) analysis. The XRD results showed a crystalline and amorphous phase which contribute to magnetite and isinglass respectively. Moreover, the formation of the core/shell structure had been confirmed by TEM images. The synthesized Fe 3 O 4 @SiO 2 /ECH/IG was applied as a bifunctional heterogeneous catalyst in the synthesis of spirooxindole derivatives through the multicomponent reaction of isatin, malononitrile, and C-H acids which demonstrated its excellent catalytic properties. The advantages of this green approach were low catalyst loading, short reaction time, stability, and recyclability for at least four runs.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-10102-5