Melatonin Treatment Improves Insulin Resistance and Pigmentation in Obese Patients with Acanthosis Nigricans

Melatonin Treatment Improves Insulin Resistance and Pigmentation in Obese Patients with Acanthosis Nigricans

Objective. This study aimed to determine the effects of melatonin on insulin resistance in obese patients with acanthosis nigricans (AN). Methods. A total of 17 obese patients with acanthosis nigricans were recruited in a 12-week pilot open trial. Insulin sensitivity, glucose metabolism, inflammator...

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Veröffentlicht in:International journal of endocrinology 2018-01, Vol.2018 (2018), p.1-7
Hauptverfasser: Qu, Shen, Song, Kexiu, Gusdon, Aaron M., Chen, Jiaqi, Wang, XingChun, Sun, Hang, Li, Liang
Format: Artikel
Sprache:eng
Schlagworte:
Acanthosis nigricans
Body fat
Body mass index
Body weight
Clinical Study
Cytokines
Diabetes therapy
Endocrinology
Glucose
Glucose metabolism
Insulin resistance
Lipids
Melatonin
Metabolism
Obesity
Patients
Peptides
Physiological aspects
Physiology
Tumor necrosis factor-TNF
Type 2 diabetes
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Zusammenfassung:Objective. This study aimed to determine the effects of melatonin on insulin resistance in obese patients with acanthosis nigricans (AN). Methods. A total of 17 obese patients with acanthosis nigricans were recruited in a 12-week pilot open trial. Insulin sensitivity, glucose metabolism, inflammatory factors, and other biochemical parameters before and after the administration of melatonin were measured. Results. After 12 weeks of treatment with melatonin (3 mg/day), homeostasis model assessment insulin resistance index (HOMA-IR) (8.99 ± 5.10 versus 7.77 ± 5.21, p
ISSN:1687-8337
1687-8345
DOI:10.1155/2018/2304746