Comprehensive evaluation of some phagocytosis parameters in children aged 2–5 years, depending on the incidence of acute respiratory infections

Background. After respiratory virus infection, there is an increased production of pro-inflammatory cytokines, inclu­ding tumor necrosis factor (TNF) α, interleukin (IL) 6, ­IL-1β that leads to cross-activation of the neuroendocrine immune system, which can impair phagocytosis with an increase in the incidence of upper respiratory tract infections (URTI), forming a vicious circle. The aim: to increase the effectiveness of diagno­sing immune disorders in children aged 2–5 years with recurrent URTI by means of a comparative analysis of data obtained based on the study of some parameters of phagocytosis, serum levels of pro-inflammatory cytokines and lipid peroxidation products. Materials and methods. Sixty children aged from 2 to 5 years were under observation, two groups were formed: 1) patients with recurrent URTI (n = 30); 2) children who suffer from URTI less than 6 times a year (n = 30). Results. The children of group 1 had increased frequency of registration of low indicators of the phagocytic number (by 60.0 %, p